302 research outputs found

    Polyfunctional heteroaromatic fused ring systems

    Get PDF
    Many current therapeutic agents are based on a core structure consisting of a fused ring heteroaromatic polycyclic system. Methodology for the synthesis of a range of these structurally diverse heteroaromatic derivatives is therefore highly desirable and short, high yielding, regioselective and flexible routes to such systems is very important. Our methodology utilises nucleophilic substitution reactions between pentafluoropyridine (PFP) and its derivatives, and various binucleophiles, e.g. The methodology has also been extended to 4-substituted tetrafluoropyridine derivativesand different binucleophiles, resulting in the successful synthesis of, among others, the system shown below. These fused systems are also reactive to further nucleophilic substitutions

    Strengthening links between social protection and disaster risk management for adaptive social protection in Nepal

    Get PDF
    A key challenge in Nepal is the intersection of predictable chronic or seasonal poverty andvulnerability, with rapid-onset and acute shocks. Nepal in the last few decades has epitomized the'perfect storm' in which a number of different factors—disasters, conflict, political uncertainty, and challenges to economic growth—coincide with deleterious effects on people's well-being anddevelopment progress. While social protection (SP) is playing an increasing role in tackling chronic and seasonal poverty and wider vulnerability and exclusion, recent disasters in Nepal, particularly in 2015, highlight how making SP more flexible and adaptive could allow a more effective and efficient development and humanitarian response. The World Bank in Nepal contracted the Centre for International Development and Training at the University of Wolverhampton, United Kingdom, and the Nepal Institute for Social and Environmental Research, to carry out the technical assistance (TA) project 'Review of policies, systems and programs in social protection and shock response for adaptive social protection in Nepal'. The overall objective of the work is to make recommendations on possible policy, programmatic, and institutional measures for more adaptive social protection (ASP). The analysis was delivered using a mixed-methods approach. An analysis of existing data (including the Household Risk and Vulnerability Survey [HRVS] data) was used to understand the scope and coverage of existing programs and their links to disasters and shocks. A desk review of literature explored legislation and policies, program documentation and official implementation guidelines, and evaluations and research. Interviews took place with key informants at the national, district, and local government levels as did focus group discussions (FGDs) and individual interviews, especially with recipients of SP programs, at the ward or village level in the districts of Bardiya, Humla, Saptari, and Sindhupalchok.World Bank - P16351

    Sustaining existing social protection programmes during crises: What do we know? How can we know more?

    Get PDF
    Published by the Institute of Development Studies under an Open Government licence.Research on social assistance in crisis situations has focused predominantly on how social assistance can flex in response to rapid-onset emergencies such as floods or hurricanes and to slower-onset shocks such as drought. This paper identifies a substantial knowledge gap – namely, our understanding of the ways in which existing, government-led programmes can be sustained during crises to ensure that households that were already poor and vulnerable before a crisis continue to be supported. The limited literature available focuses on climate- and natural environment-related shocks – far less attention is paid to other crises. Conflict-affected situations are a major gap, although there is an emerging body of evidence of the ways in which focus on adapting delivery mechanisms has allowed social assistance and other social protection programmes to be sustained throughout the Covid-19 pandemic. The paper concludes that a better understanding of when, where and how existing programmes can be sustained during situations of violent conflict will help to ensure that poor and vulnerable households can be supported – either through government programmes or by enabling robust diagnosis of when efforts to sustaining existing programmes will be inadequate and an additional, external responses are required.Published onlin
    corecore